Irma hit southwestern Florida on Sunday morning as a Category 4 storm, the second most severe on the five-step Saffir-Simpson scale.
Teams of emergency workers rescued more people from flooded communities, repaired roads, cleared debris and started restoring power to millions of residences and businesses.
Keys residents are now returning to their homes, with the Florida Department of Transportation saying all 42 bridges along US 1 - the only road into and out of the Keys - have been inspected and cleared.
"EMCs stress that damage from Irma is a historic outage event in Georgia and it will take days to completely replace or fix power lines and power poles in every corner of the state", the statement said.
Patrica Morrow, a resident of Islamorada, a village made up of multiple islands that are a part of the Keys, works as a housekeeper and stayed on the Keys during the storm, taking refuge at her employer's Islamorada home.
The storm killed at least 40 people, five of them from the USA, according to the news station. Chatham County, which includes Savannah, sustained massive flooding due to the storm, a surge of 4.7 feet and a high tide, known locally as a king tide.
The pharmacy turned out to be one of the few, if not the only one, remaining open in Central Florida before and after the hurricane.
The effects of the storm, as seen from above the Keys.
"That's good for us", Sine said.
"For those people who left, they don't know when they're getting back in", she said.
Many places including Miami Beach were just beginning to reopen, and highways leading into the state from Georgia had bumper-to-bumper traffic. And the governor said damage on the southwest coast, including in Naples and Fort Myers, was not as bad as feared. The storm's winds, heavy rain and surging seas have crippled the state after 6.5 million people were ordered to evacuate to other areas. Georgia Power and Alabama Power are subsidiaries of Atlanta-based Southern Co.
Carbon monoxide expelled by generators has killed one man in SC and sent two people to the hospital in Florida. That includes a 57-year-old man struck by a tree limb during the storm in Calhoun Falls; a 54-year-old man who died in a mobile home because of carbon monoxide poisoning while a generator was running; and a man who died in a auto crash in Richland County.
More than 180,000 people huddled in shelters in the Sunshine State. Authorities also reported the death of a driver with a Florida license plate, but they gave no details. In Sandy Springs, a man died while lying in bed after a large tree broke and fell on his home, the Sandy Springs Mayor said.
The company is focusing its efforts first on schools, hospitals and other critical infrastructure.